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Contraindicated. Coadministration not advised; sturdy cytochrome P450 enzyme inducers minimize systemic exposure to roflumilast and may lessen the therapeutic usefulnessObserve Carefully (one)phenobarbital will decrease the extent or outcome of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Lack of,